In 2011, Ouyang Nana won the championship of the cello competition in Taiwan, China, China, and walked into the music class of the High School Affiliated to Taiwan, China Normal University as the first top performer.

In 2014, she rose to fame in the film and television industry by playing the role of Liu Xingyang, a young cello girl, in "Beijing Love Story".

In 2015, he held a solo concert at the National Centre for the Performing Arts in Beijing, becoming the youngest performer to hold a solo concert since the opening of the theater in 2008; In August, she starred in the movie "Breaking the Wind" and played the role of Chen Yiqiao. She was nominated as the best female supporting role at the 7th Macao International Film Festival for this play.

In 2016, she starred in the TV drama "Yes! Mr. Shang" with Chen Xuedong, playing the female lead role of Lu Xiaogui. This was her first TV drama starring her.

In 2020, performed the song and dance "Tomorrow Will Be Better" at the CCTV Spring Festival Gala.

In 2021, attended the event "2020 Sina Weibo Night" held in Shanghai and was awarded the title of "Weibo Annual Enterprising Artist".  

In August 2023, the first Mandarin creative album of 2023 titled 'The Star' will be released.

In 2024, the first native mother daughter emotional reality show of Mango TV, "Daughter is Mother", was broadcast, and participated in the program together with mother and two sisters. In August, she participated in the reality show "Weekend 2024 as Good Friends" with Luan Yunping, Zhu Yunfeng, and others.  

On May 17, 2025, the movie "Unique" in which he participated was released.