In 2004, Ke Jiayuan was discovered by a talent scout and appeared in the music video for Jay Chou's "Maple".

In 2006, Ke Jiayuan, who used to be a kindergarten teacher, officially debuted after starring in the movie "At the Beginning of a Year".

On February 5, 2010, she starred in the drama film "Monga" and played the first female lead, Xiao Ning. In order to portray Xiao Ning well, she wrote an autobiography specifically for the character and discussed it with the director. With this role, she was nominated for Best Actress at the 12th Taipei Film Festival and began to make a name for herself in the film industry.

In 2011, she starred in the romantic and inspirational drama "Little Capitalist Girls Charge Forward".

In January 2014, the New Year comedy film "Iron Lion Jade Linglong" starring was released.

On May 5, 2015, the costume mythology drama "Liaozhai New Edition" starring Ke Jiahua and Qiao Zhenyu was broadcasted. This drama was Ke Jiahua's first time playing a costume drama; On November 1st, the career romance inspirational drama "Must Marry a Woman" starring Ke Jiahua was broadcasted. Ke Jiahua portrayed the female lead in the drama with rich and delicate colors, making her cute and moving. She also won the Best Actress Award at the 51st Golden Bell Awards for her performance in the drama.

On March 18, 2016, the starring urban love comedy Five Star Dried Fish Girl was released in Taiwan, China, China; In December, participated in the movie 'The Ferryman'.

In 2020, the suspense drama "I Want to See You" starring her won a lot of attention and praise on both sides of the Taiwan Strait, and she also won the Best Actress Award at the 55th Golden Bell Awards for her performance.

In 2023, release a personal single 'Obsessed with Enlightenment'; On March 31st, the TV drama "Imitation" co directed by Zhang Rongji and Zhang Hengru was broadcasted; On November 1st, the modern racing drama "The Speed Paradox" starring was broadcasted; On November 19th, the variety show "Sweet Mission" that participated in the recording was broadcasted.

In 2025, the Netflix dramas "Fairy Tales Part 2" and "If I Haven't Seen the Sun Season 2" will be released.