In 2011, Zhao Yihuan signed an agreement with IFG, an Internet film group, to officially enter the performing arts industry; In July, she made her debut in a movie and played the leading role of Cheng Xiaoyu in the youth inspirational film "Adolescence" directed by Guan Xiaojie.

In October 2012, Zhao Yihuan released her first solo single "Hello Huan".

Afterwards, Zhao Yihuan starred in films such as "Female Enemy", "Reserve Flight Attendant", and "The Ultimate School Flower".

In February 2016, Zhao Yihuan participated in the CCTV 2016 Dream Public Welfare Ceremony, singing the song "I am a Girl" to raise funds for children's public welfare projects; In March, she participated in the recording of LeTV's original variety show "Beauty Battle", which received high praise after its broadcast. She gradually returned to the audience's field of vision and also moved towards diversified development.

Afterwards, Zhao Yihuan successively appeared in film and television works such as "708090: Shenzhen Love Song", "School Flower prequel: Pure and Ambiguous", "April of the Stars", and "Women's Rules".

On October 11, 2023, Zhao Yihuan starred in the suspense drama "Plum Blossom and Red Peach" and played the role of Zhang Shuyun.

On April 7, 2025, the TV drama "Detective Hunter Zhan" featuring Zhao Yihuan was broadcasted.