In 2006, Meng Li won the "Best Photogenic Award" and "Most Promising Celebrity Award" on the "Variety Show Starry Sky" program.

In 2011, Meng Li won the "Asian Newcomer Award" at the Shanghai Film Festival.

In 2012, Meng Li made her debut in a film as the female lead in the collaboration with actors such as Wen Wen, Qin Hailu, Li Wei, Huang Weide, and others in the film "Truth or Dare". Later, due to her involvement in various advertising shoots, she caught the attention of Fan Xiaotian.

In 2013, Meng Li played the role of Yuwen Nan in the CCTV New Year drama "Tang Dynasty Romantic Hero" and gained popularity; In the same year, she played Ding Yiya in the popular drama "Baby" written by Liu Shi. Due to the ratings breaking three, she gained widespread attention and also served as the female lead in the TV drama "Flipping Hands for Clouds and Rain".

On August 4, 2014, the urban emotional life light comedy "Divorce Lawyer" starring Meng Li was broadcasted.

In 2018, Meng Li won the Golden Oak Award for Best Potential Actress at the Asian Film and Television Festival in the United States.

In 2019, Meng Li starred in the TV drama "Banna Fengyun".

On August 14, 2021, the ancient martial arts drama "The Legend of the Condor Heroes" starring Meng Li was broadcasted.

On July 11, 2022, the suspenseful crime web drama "Dark Blade Awakening" starring Meng Li was released, portraying Wenjing.

On June 2, 2024, Meng Li appeared in the TV drama "Mo Yu Yun Jian" and was broadcasted.