In December 2016, she starred in the competitive youth campus drama "E-sports Era" directed by Sun Fang, thus officially entering the entertainment industry.

In December 2017, she won the Tencent Video Starlight Awards for the Most Promising TV Drama Actress of the Year for her role as "Yanzi" in the web drama "The Ghost Blows Out the Light: The Yellow Skin's Grave". The following year, she played the role of "Chen Xinyue", a white-collar worker in the urban workplace romantic comedy "Brave Forward to Fall in Love with You", and her natural performance resonated with the audience.

In March 2021, the fantasy drama "Situ Teng", starring Jing Tian and Zhang Binbin, premiered. In the drama, she took on the role of the villain "Shen Yindeng" for the first time and attracted much attention from the audience.

In June 2022, the ancient costume inspirational drama "Dreams of Splendor" was aired on Tencent Video. She played the role of the intelligent and witty "Ge Zhaodi", and was recognized and loved by the audience for her precise portrayal of the character. She was also nominated for the Best New Actress of the New Era at the 3rd New Era International TV Festival's Colorful Snail Awards for this role.

Since 2023, Li Muchen has embarked on the path of short dramas. The short dramas he starred in, "Qi Miao, Please Smile", "The Revenge of a Film Queen", and "Provoke", have been aired one after another. Among them, she played the role of "Jiang Ying" in "Zhaoju", and gained the public's intense attention with her sense of redemption and the stunning makeup and styling in the drama.

In May 2024, the modern legend drama "Tianxingjian" in which she starred was aired.

On April 5, 2025, Yu Zheng made public the relationship between Li Muchen and Liu Yichang. On July 29th, the drama "The Dragon Son-in-law Who Comes to the Door" starring Lingjie officially started shooting.