In 2018, he signed with Jiaxing Media and officially debuted as an artist under its umbrella.

In 2019, the youth romance drama "You Are the Mountains, Rivers, and Oceans in My Eyes" was broadcasted as the lead actor.

In 2020, the historical fantasy romance drama "Three Lives, Three Generations, Pillow Letter" co starring with Dilraba and Gao Weiguang was broadcasted, in which he played the role of Chonglin, the personal guard of the Emperor; On June 17th, the film "99% Girlfriend" premiered, in which he played the role of young and promising plastic surgeon Sui An. This was his first time challenging a role that was vastly different from his actual age and image; On July 16th, the "3rd Super Star Sports Games" jointly launched by Tencent Sports and Tencent Video was broadcasted. Fan Zhixin, along with actors A team consisting of Ao Ruipeng, Zhao Yiqin, and Zhou Junwei, won the men's basketball 3V3 final.

In 2021, the performances of "Miss Raven and Mr. Lizard," "Wild Goose Returns to the West Window Moon," and "Secrets of the Dark Grid" were successively broadcasted.

On March 3, 2022, the costume light comedy "Xie Gongzi's Wine", starring Xie Xun and Xie Tuisi, premiered on Tencent Video.

On January 13, 2023, the suspenseful love urban drama "He Who is Dangerous to Me" starring with Li Mozhi was broadcasted. This was the first time that Fan Zhixin and Li Mozhi formed a on-screen couple; On February 13th, she starred in "The Diary of Wendrella" and played Su Ziguang in the drama; On March 24th, the historical legal drama "Miss Spring is a Lawyer" starring Zhuang Dafei and Huang Junjie was broadcasted, in which she played the role of Han Wuwei, the unrestrained commander of the Zhechong Mansion.

On January 25, 2024, Fan Zhixin won the "Outstanding Actor Award" at the iQiyi Split Account Drama Seventh Anniversary Ceremony; On April 8th, the web drama "Trapped" starring started filming; On May 21st, the TV drama "You Who Run to All Time and Space" starring Fan Zhixin, Tu Bing, Wu Haoze, and others was broadcasted, in which she played Wei Ziqi.

In 2025, the TV drama "Beloved Game" in which he participated will be broadcasted.